for me modern threat come from different direction nowadays,there is roque(fake antivirus,antimalware,firewall),trojan,virus,worm,keylogger,etc.
For antivirus i prefer multi-engine antivirus(gdata,etc),for single engine i prefer avira/kaspersky,anti malware i prefer antimalware byte and pctools antispyware,for trojan i pick anti malwarebyte,i always check for every year if the performance of this following setup would be still top notch because AFAIK brand doesn't always tells quality over years,there is always be performance degradation over several months/years and i always check for performance on forum(http://www.wilderssecurity.com/) or any independent review site which right now there is so many review site that are clouded by vendor money offer.Forgot to mention i also doing internal self test of any product that i interested to use using VM(virtual machine),folder,registry side by side comparing(clean vs infected) just to double make sure that the independent forum/review site are really independent
,most of the reviewer on youtube are to be honest quiet amateur,mostly they just comparing live sample (-2 weeks/0day),reviewer forgot to add the aftermath of virus cleaning effect(system files,registry,files) by the product.
Now i run :
Windows 7 64 Bit
Avira Pro 32 bit (realtime)
AntiMalwarebyte (on demand)
PCTools antispyware(on demand)
Prevx(realtime)
Hitman(on demand)
Outpost Firewall pro(realtime)
Why?it's from my own internal research
.