Deleting a file in use without rebooting

#include <windows.h>

int main(int argc, char **argv)
{
HMODULE module = GetModuleHandle(0);
CHAR buf[MAX_PATH];

GetModuleFileName(module, buf, sizeof(buf));
CloseHandle(HANDLE(4));

__asm {
lea eax, buf
push 0
push 0
push eax
push ExitProcess
push module
push DeleteFile
push UnmapViewOfFile
ret
}

return 0;
}

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Something like this may do what you are wanting with some modifications. Caveat, I have used this for self-deleting executables as they run in memory.